Director, People Operations & Total Rewards

Andreessen Horowitz (a16z)
DirectorVenture Capital
Date Posted

March 23, 2026

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About This Role

Job Application for Director, People Operations & Total Rewards at Formation Bio

Formation Bio is a tech and AI driven pharma company differentiated by radically more efficient drug development.

Advancements in AI and drug discovery are creating more candidate drugs than the industry can progress because of the high cost and time of clinical trials. Recognizing that this development bottleneck may ultimately limit the number of new medicines that can reach patients, Formation Bio, founded in 2016 as TrialSpark Inc., has built technology platforms, processes, and capabilities to accelerate all aspects of drug development and clinical trials. Formation Bio partners, acquires, or in-licenses drugs from pharma companies, research organizations, and biotechs to develop programs past clinical proof of concept and beyond, ultimately helping to bring new medicines to patients. The company is backed by investors across pharma and tech, including a16z, Sequoia, Sanofi, Thrive Capital, Sam Altman, John Doerr, Spark Capital, SV Angel Growth, and others.

At Formation Bio, our values are the driving force behind our mission to revolutionize the pharma industry. Every team and individual at the company shares these same values, and every team and individual plays a key part in our mission to bring new treatments to patients faster and more efficiently.

Formation Bio is looking for a Director of People Operations & Total Rewards to own the strategy and execution of our people infrastructure.

Reporting to the SVP, Head of People, you'll drive outcomes that advance company priorities by building compensation expertise in-house, designing scalable people programs, and ensuring operational excellence across our systems and processes. This is a high-impact role for someone who can make independent, complex decisions with a company-wide perspective by evaluating tradeoffs in compensation strategy, benefits design, and program implementation while anticipating long-term implications for our unique business model.

We're looking for someone who brings genuine enthusiasm for AI innovation and automation. Someone who believes people operations can be deeply human while leveraging AI to drive efficiency and scale. You'll be instrumental in building an AI-native people function that reflects Formation's broader mission and culture.

This role will cover three key areas critical to the success of the People function and business:

Drive AI-native operations across the people function - identifying opportunities to leverage technology while maintaining the human elements of our work

Ensure compliance and evolve our people processes to ensure they are fit for purpose as the business scales

Lead cross-functional processes and partner with internal stakeholders including Legal, Finance, Tech Ops, and Quality Assurance

Serve as escalation point for complex operational issues, benefits decisions, and compensation situations

Manage external vendor relationships and consult...

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