Venture Capital Firms in the US

111° West Capital is a multi-stage investment firm that partners with commercial-stage enterprise software companies focused on transforming healthcare delivery and operations.The firm combines a dedicated investment team with an Operator network to provide a hands-on, growth-oriented approach intended to accelerate revenue, scale operations and drive successful exits for portfolio companies.111° West Capital’s public materials and industry profiles indicate a primary focus on digital health and enterprise healthcare software investments, and that the firm was founded in 2021 and is active across stages from commercial growth rounds through Series A/B in its areas of expertise.

137 Ventures is a San Francisco‑based private investment firm specializing in providing liquidity solutions and growth capital to founders, early employees and angel investors in high‑growth technology companies. Founded in 2011, the firm manages over US$5 billion across funds that purchase private company shares on the secondary market and participate in primary growth rounds. 137’s approach allows early stakeholders to realize liquidity without forcing a premature sale or IPO, while enabling companies to continue compounding value privately. Its portfolio includes some of Silicon Valley’s most iconic names in enterprise software, fintech, consumer internet and mobility. In addition to capital, the firm offers strategic support, including introductions to later‑stage investors, guidance on secondary market dynamics and advice on navigating complex cap‑table structures. The team maintains strict confidentiality and aims to align with both founders and early shareholders by structuring transactions that work for all parties. 137 Ventures’ culture emphasizes long‑term thinking, integrity and the belief that providing liquidity at the right time can be a catalyst for innovation, allowing founders and employees to focus on building rather than managing personal finances.

1789 Capital Management, LLC is an American venture capital and growth equity firm headquartered in Palm Beach, Florida. The firm was founded in 2022 and is led by a team that includes Omeed Malik, Rebekah Mercer, and Chris Buskirk. 1789 Capital positions itself as an anti-ESG investor that promotes the philosophy of "patriotic capitalism" and advocates for investment opportunities aligned with conservative values, deglobalization, and U.S. national interests.The firm targets late-stage high-growth companies in the U.S., investing across a range of sectors with a primary focus on defense technology, artificial intelligence, digital infrastructure, fintech, and energy. Typical deal sizes range from $5 million to $50 million, with an investment thesis aiming for 3-5x returns over a 2-4 year horizon.Notable portfolio companies include Anduril, Neuralink, and SpaceX, among others. As of September 2025, 1789 Capital's assets under management (AUM) stand at $861 million. The firm has plans for expansion into multi-strategy asset management and real estate investment, with a significant $1 billion real estate fund planned for South Florida.1789 Capital leverages its extensive political networks for added value, particularly in areas such as government contracts and reshoring endeavors. The firm also maintains an office in Scottsdale, Arizona, and is registered in Delaware.

1984 Ventures is a venture capital firm founded in 2017 and headquartered in San Francisco, California. Inspired by Apple’s iconic “1984” Macintosh launch, the firm champions the belief that nimble, software-driven startups can challenge and transform industry incumbents. The firm invests primarily at the pre-seed and seed stages, focusing on founders with grit, industry insights, and strong engineering culture. 1984 Ventures operates with a collaborative, founder-friendly approach, typically investing via SAFE or equity without taking board seats. The firm provides hands-on support in recruiting, fundraising, and preparing portfolio companies for successful Series A rounds. It also publishes a public Founders Handbook to guide early-stage teams on topics ranging from cap tables to Series A preparation and open-source strategy. The firm’s portfolio includes over 120 investments, with notable companies such as Fairmarkit, Reggora, BuildOps, Convex, Kyte, and PadSplit. 1984 Ventures has achieved multiple exits and continues to back innovative startups across sectors like SaaS, AI, fintech, proptech, logistics, and healthcare, with a strong presence in the United States and selective investments in Europe and Latin America.

1Flourish Capital is a venture capital firm focused on investing in early-stage, disruptive technology startups led by founders of high character who are on missions to advance human flourishing. Beyond providing capital, 1Flourish actively supports its portfolio companies through strategic guidance, leadership training, and cultivating exceptional company cultures based on principles such as trust, humility, and accountability. Their approach emphasizes building enduring values and sustainable success in their investments. The firm leverages the expertise of advisors like Patrick Lencioni and The Table Group to help founders develop strong leadership and governance practices. 1Flourish’s team has extensive experience managing over $1 billion in venture capital and private equity, with backgrounds including serial entrepreneurship, technology leadership, and operational excellence. This deep operational and investment experience enables them to nurture portfolio companies effectively. 1Flourish primarily invests in the United States, focusing on sectors such as e-commerce and enterprise technology. Their investment style is collaborative and operator-led, emphasizing disciplined scaling of innovative businesses. The firm is known for its commitment to principled leadership and high-performance company cultures, aiming to back visionary technical founders poised to scale solutions that enhance human well-being.

500 Global (formerly 500 Startups) is a global venture capital and accelerator firm founded in 2010 by Dave McClure and Christine Tsai. Headquartered in San Francisco with a global presence, the firm supports founders through accelerator programs, mentorship, and capital. The firm manages approximately US $2.3 billion in assets and has backed over 5,000 founders across more than 2,500 startups in over 80 countries. Its portfolio includes more than 30 unicorns and many high-growth companies exceeding US $100 million in valuation. 500 Global specializes in early-stage investments across sectors such as fintech, AI, SaaS, e-commerce, health-tech, and enterprise software. Through programs like its flagship accelerator and VC Unlocked, it equips founders and emerging investors with the knowledge, networks, and tools needed to scale globally.

8VC is a technology and life‑sciences venture capital firm founded in 2015 by Joe Lonsdale, Drew Oetting, Alex Kolicich, and Jake Medwell. Originating in San Francisco and now headquartered in Austin, Texas, the firm brings together operators, technologists, and policy thinkers to invest in startups built to solve deep infrastructure and societal challenges. With over $6 billion in committed capital and a portfolio of more than 350 companies, 8VC invests across pre‑seed through growth stages in areas such as logistics, defense, enterprise software, healthcare, life sciences, manufacturing, financial services, and IT infrastructure. The firm also operates a proprietary “Build” program to launch new companies and a fellowship to attract top talent to its portfolio. Driven by a mission to "fix a broken world," 8VC backs transformative entrepreneurs building long‑term value in sectors often overlooked or deeply entrenched. Notable investments include Anduril, Epirus, Palantir, Guardant Health, and Hyperloop One, reflecting the firm’s belief in principled contrarianism and societal impact.

ACME Capital is a forward-thinking venture capital firm dedicated to supporting early-stage startups that are building transformative technologies. With a focus on bold entrepreneurs and disruptive ideas, ACME Capital partners with founders from seed to growth stages, providing capital, strategic insight, and long-term support. The firm is deeply rooted in Silicon Valley’s innovation ecosystem and operates with a global outlook. The firm has developed a strong track record of successful investments across frontier technology, enterprise software, and digital platforms. ACME Capital prioritizes ventures that demonstrate scalable potential, technical depth, and the ability to fundamentally improve industries. Its portfolio includes a mix of trailblazing companies that are redefining sectors like AI, robotics, cybersecurity, and digital health. ACME Capital’s team brings together decades of operational experience, domain expertise, and a collaborative approach to venture investing. Beyond financial backing, the firm acts as a hands-on partner to its portfolio companies, offering guidance on product development, go-to-market strategies, and follow-on fundraising. By staying agile and founder-focused, ACME Capital continues to identify the next generation of global leaders in tech.

Adams Street Partners is a leading global private markets investment manager headquartered in Chicago. Established in 1972, the firm has over five decades of experience in private equity, offering a comprehensive suite of investment strategies including venture capital, growth equity, buyouts, private credit, and secondary investments. The firm is 100% employee-owned, fostering a culture of alignment and long-term commitment to its clients. With a presence in more than 30 countries across five continents, Adams Street Partners leverages its extensive network and deep industry insights to identify and capitalize on investment opportunities. The firm's global footprint includes offices in key financial centers such as Austin, Beijing, Boston, London, Menlo Park, Munich, New York, Seoul, Singapore, Sydney, Tokyo, and Toronto, enabling it to maintain close relationships with portfolio companies and investors worldwide. Managing approximately $62 billion in assets under management, Adams Street Partners serves a diverse client base comprising corporate and public pension plans, foundations, family offices, and endowments. The firm's commitment to excellence and innovation in private markets investment management has solidified its reputation as a trusted partner for institutional investors seeking long-term value creation.

Adaptation Ventures, founded in 2025, is a U.S.-based angel investor network dedicated to supporting early-stage startups that develop accessible technologies benefiting the global disability community. Recognizing the vast market potential and the underrepresentation of disability-focused innovations, the firm aims to bridge the funding gap in this sector. The firm typically invests a minimum of $250,000 in each company that passes its due diligence process. Adaptation Ventures is sector-agnostic, considering investments in both B2B and B2C startups that provide technology, services, or products for any part of the disability market and community. The group conducts quarterly virtual meetings where selected startups pitch to members, followed by a structured due diligence process. Co-founded by Brittany Palmer and Rich Palmer, both of whom have personal experiences with disabilities, Adaptation Ventures brings a unique perspective to the investment landscape. Brittany previously founded Beeyonder, a virtual travel startup for people with disabilities, while Rich co-founded Gravyty, an AI company for social good. Their combined experiences drive the firm's mission to unleash innovation in the world's largest overlooked market.

Adverb Ventures is an early-stage venture capital firm that partners with founders to build enduring, breakout companies; the firm emphasizes how companies are built — “the adverbs matter as much as the verbs.”Founded by former operators and investors with product and leadership experience at companies such as Twitter, Slack, and Robinhood, Adverb runs programming and community events for founders and curates an operator-led approach to support portfolio teams.The firm’s portfolio includes companies across AI, enterprise software and consumer technology (examples listed on their site include Cove, Hypernatural, Shotsy, Outset AI and others), and it actively convenes founders through events, retreats and newsletters to deepen founder connections and operational support.

AE Industrial Partners (AEI) is a private equity firm specializing in control investments in aerospace, defense & government services, space, power & utility services, and industrial technology. Founded by experienced industry executives, AEI brings deep operational expertise and strategic resources to its portfolio companies, focusing on accelerating growth, innovation, and long-term value creation. AEI’s investment philosophy centers around partnering with management teams to transform and scale businesses in highly technical and regulated sectors. The firm’s team combines financial acumen with sector-specific insight to identify and build companies that are well-positioned to lead in their markets. AEI typically targets companies with strong engineering capabilities, defensible market positions, and opportunities for operational enhancement or strategic consolidation. With headquarters in Boca Raton, Florida, and offices in Washington D.C. and Los Angeles, AE Industrial Partners is active across North America. The firm manages multiple funds and strategies, including private equity, venture capital, and structured capital solutions, allowing for flexibility across the capital stack. AEI has earned a reputation as a leading investor in the aerospace and defense ecosystem.

Aglaé Ventures is a technology-focused investment firm created to fund and support ambitious founders building fast-growing, asset-light companies. Backed by Agache (formerly Groupe Arnault), the principal investment vehicle of Bernard Arnault, it operates from Paris with offices in New York and San Francisco. The firm invests broadly across stages — from seed and Series A through Series B to pre-IPO — and deploys ticket sizes from approximately €100K (seed) up to €100M (growth/pre-IPO), targeting marketplaces, software (SaaS and open-source), content and consumer platforms, developer and app tools, and digitally native vertical brands among other asset-light models. Aglaé emphasizes long-term capital, operational support (growth management, brand building, digital marketing, and global expansion), and access to an extensive network including the LVMH ecosystem and global tech founders and investors to help portfolio companies scale globally.

Album VC is a venture capital firm founded in 2014 (rebranded from Peak Ventures in 2019), headquartered in Lehi, Utah. Focusing exclusively on early-stage technology ventures, Album backs founders building innovative software, SaaS, fintech, healthcare services, life science, and oncology companies with high growth potential. The firm operates with a streamlined team of 2–10 employees, emphasizing close, founder-first partnerships. Since its founding, Album has made nearly 190 investments, including early bets in well-known startups such as Podium, Divvy, Neighbor, Filevine, TaxBit, MX, Andela, and Weave. Album VC III (2020 vintage), its flagship fund, targets software, SaaS, life sciences, healthcare services, TMT, and oncology companies, deploying initial checks typically between $1 million and $1.5 million per company.

Alexandria Venture Investments is the strategic venture capital arm of Alexandria Real Estate Equities, Inc., a leading developer of life science and technology campuses. With deep roots in the biotech and healthcare sectors, the firm invests in transformative early- to growth-stage companies that are shaping the future of life sciences, diagnostics, digital health, and agtech. The firm leverages its unique position within Alexandria's ecosystem to provide more than just capital—it offers access to cutting-edge facilities, industry expertise, and a vast network of scientific and corporate leaders. Alexandria Venture Investments is known for its active partnership model, working closely with founders and management teams to accelerate innovation and growth. Focused on advancing solutions that address critical global health challenges, the firm targets companies with strong scientific foundations and scalable platforms. Its portfolio includes some of the most promising startups and industry leaders across North America and select global markets.

Alpha Square Group (ASG) is a dynamic New York-based investment firm and single family office managing over $1 billion in assets under management (AUM). Registered with the U.S. Securities and Exchange Commission, ASG invests across public and private markets, supporting cutting-edge companies and top-tier managers driving innovation globally. The firm's strong expertise facilitates exceptional returns while fostering technological advancements.ASG focuses on high-growth sectors including Enterprise SaaS, Fintech, Crypto/Web3, and AI. It emphasizes investments in Series B to Pre-IPO stage companies that demonstrate rapid revenue growth, with a run rate of at least $5 million. The typical investment size ranges from $3 million to $15 million, and ASG often participates in follow-on funding rounds to further support its portfolio companies.Headquartered in New York City, ASG operates with a team of 11 to 50 employees. The firm primarily targets opportunities in the USA but also engages with global investments, including significant exposure to Canadian and Asian markets. ASG provides value through market trend analysis and compliance with regulatory frameworks, aiming to enhance both financial returns and strategic development in its portfolio.

Alumni Ventures (AV) is an American venture capital firm founded in 2014 and headquartered in Manchester, New Hampshire. It specializes in democratizing venture capital by providing accredited individual investors with simple, diversified access to high-quality venture deals typically reserved for institutional investors. AV operates as a co-investor alongside elite venture capital firms such as Andreessen Horowitz, Sequoia, and Y Combinator, without leading rounds or taking board seats.With over $1.5 billion in assets under management and a community of more than 11,000 individual investors and 850,000+ community members, AV manages approximately 45 funds including alumni-focused funds and sector-specific "Focused Funds" in areas like health, sports, and artificial intelligence. The firm offers two main investment vehicles: diversified annual funds with 20-30 companies and deal-by-deal syndicates, allowing investors to tailor their exposure.AV is recognized for its rigorous due diligence, network-driven deal sourcing, and strong investment performance, earning accolades such as Top-Decile DPI Investment Performance (Carta ’25), Top 20 Venture Firm by CB Insights (2024), and inclusion in Inc. Magazine’s Most Founder-Friendly Investors (2024). The firm supports portfolio companies through CEO Services, including networking, warm introductions, pitch practice, and workspace access across multiple US and international offices.

Amboy Street Ventures is the world’s first venture capital fund dedicated exclusively to Women’s Health and Sexual Wellbeing for all genders. Founded in 2020 and headquartered in Los Angeles, California, the firm focuses on investing in innovative startups that address critical but underserved areas such as fertility, menopause, maternal health, LGBTQ+ health, menstruation, hormonal health, sexual health, and contraception. The fund targets the untapped $1 trillion global women’s health market by supporting cutting-edge technologies and products that improve health outcomes and wellbeing.The firm primarily invests in Seed and Series A rounds, backing companies that are advancing the industry in America and Europe. Amboy Street Ventures is an active investor that adds value beyond capital through its Value Enhancement Team, which supports portfolio companies in marketing, branding, sales, product development, scientific innovation, and public education. Their portfolio includes diverse startups such as Evvy (vaginal microbiome care), Contraline (non-hormonal male birth control), HeyJane (digital abortion clinic), and Millie (modern maternity clinics).Amboy Street Ventures was founded by Carli Sapir, who leads the investment team and brings a personal passion for women’s health innovation. The team includes partners with expertise in private equity, medicine, sexual health, and marketing. The fund is named after the historic Amboy Street Birth Control Clinic in Brooklyn, symbolizing its commitment to advancing accessible and inclusive health solutions. With a focus on health equity and social reformation, Amboy Street Ventures aims to bridge the funding gap that has historically limited innovation in women’s and sexual health sectors.

Amplify Partners is an early-stage venture capital firm focused on backing technical founders who are building deep infrastructure, data, machine learning, and developer-first companies. With a distinct focus on cutting-edge software and technical innovation, Amplify invests early—often at the seed stage—to support founders shaping the future of computing. The firm thrives in complex, technical domains where deep expertise and long-term vision are essential. Founded by a team of seasoned investors and technologists, Amplify Partners provides more than just capital. The firm engages closely with portfolio companies, offering tailored support in areas such as recruiting, go-to-market strategy, product development, and fundraising. Amplify’s partners bring years of experience building and scaling developer tools, AI infrastructure, and enterprise software solutions, making them trusted advisors to technical teams. The firm primarily invests in North American companies and targets sectors including infrastructure software, security, data systems, machine learning, and open-source platforms. Amplify is known for its selective, high-conviction approach, investing in a small number of startups each year to ensure each receives focused attention and support. With a strong founder-first culture, Amplify Partners continues to be a leading voice in early-stage enterprise tech investing.

Andra Capital is a premier evergreen technology growth fund headquartered in San Francisco, focused on multi-stage investments in high-potential private technology companies, particularly those in growth and late-stage phases targeting pre-IPO opportunities. The firm supports visionary founders and management teams through a curated portfolio approach, leveraging deep domain expertise, operational experience, and extensive networks to drive superior returns and accelerate technological evolution.The team's philosophy centers on five core investment principles to identify exceptional companies with enduring technology moats and scalable business models resilient to macroeconomic cycles. Andra emphasizes funding disruptive technologies that challenge incumbents and enable new business models in an intelligent, connected digital age, with investments spanning enterprise software and other tech sectors representing over $100B in value and 100+ transactions.As an open-end and closed-end fund manager founded in 2016, Andra Capital provides investors access to Silicon Valley's private tech ecosystem with shorter exit horizons (2-3 years for late-stage) and a portfolio strategy balancing high returns with risk mitigation through diversification.