Venture Capital Firms in Washington DC

Andreessen Horowitz, also known as a16z and legally AH Capital Management, LLC, is a privately held venture capital firm headquartered in Menlo Park, California. It was founded on July 6, 2009, by tech visionaries Marc Andreessen and Ben Horowitz, initially as a $300 million seed fund. From humble beginnings, it rapidly scaled to become one of Silicon Valley’s most influential VC outfits. The firm manages approximately $42 billion in assets as of May 2024—but more recent reporting points to roughly $45 billion in committed capital by April 2025. A16z’s hallmark is an operationally focused investment model: beyond funding, it offers founders access to deep networks, strategic support, talent, and infrastructure. The firm frequently structures dedicated funds across sectors like cryptocurrency, biotechnology, generative AI, gaming, and what it terms ‘American Dynamism’ (defense and industrial tech). As a stage‑agnostic investor, a16z participates in seed rounds as well as late-stage and growth financing across multiple verticals: AI infrastructure and applications, consumer platforms, fintech services, healthcare and bio tech, enterprise IT (cloud, security, SaaS), gaming, and education. The firm also recently pursued a record $20 billion megafund focused on growth‑stage AI startups in the U.S., underscoring its ambition in catalyzing emerging tech leaders.

Epsilon is a venture capital firm dedicated to investing in early-stage companies that are transforming the U.S. healthcare system. With a clear focus on the intersection of healthcare services and technology, Epsilon backs startups that enhance care delivery, improve patient experience, and reduce costs across the healthcare continuum.Epsilon partners with passionate founders building solutions that solve systemic inefficiencies in healthcare. The firm’s portfolio spans companies in areas such as value-based care, provider enablement, tech-enabled services, behavioral health, and alternative site care. Its team brings deep operational and clinical experience, offering strategic insight far beyond capital.Based in Nashville, Epsilon targets U.S.-based opportunities and takes a hands-on approach to value creation, working closely with portfolio companies to refine business models, scale operations, and align with long-term industry shifts. The firm is committed to building enduring healthcare companies that make measurable improvements in access, quality, and outcomes.

Industry Ventures is a venture capital platform offering innovative investment solutions across the venture ecosystem. Founded in 2000, the firm specializes in secondary investments, early-stage funds, and direct co-investments. By operating at multiple stages of the venture lifecycle, Industry Ventures provides liquidity and growth capital to both emerging and established venture-backed companies and funds.The firm’s strategy is built around long-term partnerships with fund managers, entrepreneurs, and institutional investors. Industry Ventures is known for its expertise in secondary transactions, where it acquires interests in existing venture funds or portfolios of companies, offering flexible liquidity solutions. Additionally, the firm supports emerging managers through primary fund investments and enhances portfolio value through selective direct co-investments.Headquartered in San Francisco, with offices in Washington, D.C., and London, Industry Ventures maintains a global perspective with a primary focus on the U.S. venture ecosystem. The team brings together deep experience across investment, operations, and technology, managing over $7 billion in assets. Industry Ventures is widely recognized as a trusted partner in navigating the evolving venture capital landscape.

Quona Capital is a global venture capital firm founded in 2014 and headquartered in Washington, D.C., specializing in fintech investments that advance financial inclusion in emerging markets. Since its inception, the firm has established itself as a pioneer in impact investing, blending purpose with financial returns to help founders build a more financially inclusive world. With over 70 cumulative investments across fifteen countries and current assets under management exceeding USD 750 million, Quona has developed unparalleled sector expertise in emerging markets fintech innovation.The firm invests in startups expanding access to financial services for underserved consumers and small businesses, focusing on markets that are massively underserved where transformation into more equitable financial systems is possible. Beyond pure-play fintechs in payments, credit, and insurance, Quona backs startups tackling broader economic and social challenges through embedded financial solutions across supply chain, agriculture, education, commerce, proptech, health, and mobility sectors. Quona's investment strategy emphasizes early to growth-stage companies with demonstrated revenue traction, typically investing USD 2 to 6 million in equity while taking board seats for active portfolio management.Quona's heritage is rooted in a strategic relationship with Accion, a global leader in financial inclusion with over 60 years of experience. The firm's predecessor, Frontier Investments Group, was created on Accion's balance sheet, and Quona continues collaboration with Accion Venture Lab, Accion Digital Transformation Fund, and the Center for Financial Inclusion. The firm operates with a diverse, globally distributed team anchored in over 10 countries including the United States, Brazil, Mexico, India, South Africa, and Singapore, bringing deep local insights combined with global perspective.